Nonpsychotropic Cannabinoid Receptors Regulate Microglial Cell Migration
نویسندگان
چکیده
منابع مشابه
Nonpsychotropic cannabinoid receptors regulate microglial cell migration.
During neuroinflammation, activated microglial cells migrate toward dying neurons, where they exacerbate local cell damage. The signaling molecules that trigger microglial cell migration are poorly understood. In this paper, we show that pathological overstimulation of neurons by glutamate plus carbachol dramatically increases the production of the endocannabinoid 2-arachidonylglycerol (2-AG) b...
متن کاملMicroglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity.
Cannabinoid-derived drugs are promising agents for the development of novel neuroprotective strategies. Activation of neuronal CB(1) cannabinoid receptors attenuates excitotoxic glutamatergic neurotransmission, triggers prosurvival signalling pathways and palliates motor symptoms in animal models of neurodegenerative disorders. However, in Huntington's disease there is a very early downregulati...
متن کامل3-Adrenergic Receptors Regulate Retinal Endothelial Cell Migration and Proliferation*
Sympathetic nerves may play a role in vascular disorders of the eye. In the present study, we hypothesized that activation of 3-adrenergic receptors on retinal endothelial cells would promote migration and proliferation of these cells, two markers of an angiogenic phenotype. We show, for the first time, expression of 3adrenergic receptors on cultured retinal endothelial cells. Activation of the...
متن کاملHU-444, a Novel, Potent Anti-Inflammatory, Nonpsychotropic Cannabinoid.
Cannabidiol (CBD) is a component of cannabis, which does not cause the typical marijuana-type effects, but has a high potential for use in several therapeutic areas. In contrast to Δ(9)-tetrahydrocannabinol (Δ(9)-THC), it binds very weakly to the CB1 and CB2 cannabinoid receptors. It has potent activity in both in vitro and in vivo anti-inflammatory assays. Thus, it lowers the formation of tumo...
متن کاملMicroglial P2Y12 receptors regulate microglial activation and surveillance during neuropathic pain.
Microglial cells are critical in the pathogenesis of neuropathic pain and several microglial receptors have been proposed to mediate this process. Of these receptors, the P2Y12 receptor is a unique purinergic receptor that is exclusively expressed by microglia in the central nervous system (CNS). In this study, we set forth to investigate the role of P2Y12 receptors in microglial electrophysiol...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 2003
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.23-04-01398.2003